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Background & Objectives

AIM

The COST action EURO-VALDI-NET aims to create a pan-European multidisciplinary co-operative network of stakeholders, bringing together scientists, clinicians, industry partners, and patients associations, to address the vascular liver diseases problems. Through the creation of shared data registries on main relevant basic and clinical aspects, conference calls, meetings, workshops, as well as training schools, this Action will coordinate efforts aiming at advancing the understanding of vascular liver diseases to translate basic research and preclinical findings into clinical practice. For this purpose, EURO-VALDI-NET will be organized into 6 working groups:

1

Epidemiology, comprehensive clinical characterization, harmonization of biosamples collection, Risk stratification, clinical trial design in VLD

2

Comprehensive histological characterization for PSVD

3

Comprehensive radiological characterization of vascular liver diseases

4

Development of screening tools and diagnostic biomarkers for PSVD

5

Health-related quality of life (HRQoL) and patient reported outcomes (PRO) in VLD

6

Preclinical models of vascular liver diseases, identification of therapeutic targets and development of new therapeutic approaches for VLD

Objectives

  • Compile, share, and harmonize existing data and biosamples.
  • Advance understanding of VLD pathology and radiology.
  • Develop screening tools and diagnostic biomarkers.
  • Establish risk stratification methods and clinical trial designs.
  • Investigate health-related quality of life (HrQoL) and patient-reported outcomes (PROs).
  • Build preclinical models to identify new therapeutic targets.
  • Engage Young Researchers and Innovators (YRIs) and Inclusiveness Target Countries (ITCs).
  • Involve patient associations to shape research priorities.
  • Foster collaboration among clinicians, basic scientists, and industry stakeholders.

COST

COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation.

COST Actions - CA23146

Vascular liver diseases are a heterogeneous group of rare disorders characterized by an impaired vascular flow in the splanchnic and/or intrahepatic vasculature. They mainly include recent portal vein thrombosis, portal cavernoma, porto-sinusoidal vascular disorder, Budd-Chiari syndrome and sinusoidal obstruction syndrome.

Actions Contact

MoU – 059/24
CSO Approval Date – 17/05/2024
Start date – 30/10/2024
End date – 29/10/2028

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